My overall goal is to improve the treatment of metastatic disease through patient-centered translational research. My research focuses on understanding tumor-intrinsic and host determinants contributing to differences in clinical outcomes for patients with metastatic disease. We utilize integrative molecular analyses of clinical metastases, tumor models, immune and microbiome analyses, molecular biology, and statistical modeling towards translational research goals. My team aims to revolutionize cancer treatment by advancing the biological characterization of clinical metastases and optimizing the integration of localized metastasis-directed therapies with systemic treatments for the potentially curative treatment of patients with metastatic disease.