My research focuses on tumor-intrinsic and extrinsic mechanisms that promote or dampen anti-tumor T cell immunity. To that end, my group explores the molecular states of tumor-infiltrating lymphocytes (TILs) and the tumor microenvironment (TME) at various stages of tumor rejection or escape, the mechanisms of TIL exclusion and dysfunction in the TME, the role of cancer cell genomic alterations and heterogeneity in regulating the inflammation status of TILs in tumors and the development of autologous 3D TME and systems immunology models to evaluate TIL reactivity for adoptive cell therapies.