Peter Ratcliffe Lab

My laboratory is studying the mechanisms by which cells sense and signal low oxygen levels (hypoxia). Oxygen is vital to most living organisms, and the maintenance of oxygen homeostasis is a central physiological challenge for all large animals. Hypoxia is an important component of many human diseases, including cancer, anemia, cardiopulmonary and circulatory diseases. We are studying the impact of activating extensive hypoxia signalling pathways during cancer development and its implications for cancer therapeutics.