Johanna Joyce lab

Our research focuses on the microenvironment in which a tumor arises and the critical influence that non-cancerous stromal and immune cells can have on regulating tumor progression, metastasis and response to therapy.  We investigate both positive and negative signals provided by the normal tissue stroma to the cancer cells, and elucidate how normal cells can be modified by the cancer cells to produce a variety of factors that enhance tumor malignancy.